Phello ea meriana ea konofolo

Gringo o se a ngotse sehlooho se thahasellisang ka konofolo Thailand, konofolo e sebelisoa haholo lijana tsa Asia. U boetse u bona konofolo e ngata ka mefuta le boholo bo fapaneng 'marakeng oa Thailand. Sengoliloeng sena semelo se seng mabapi le thepa ea konofolo e khothalletsang bophelo bo botle. 

Tšebeliso ea meriana ea konofolo e bile teng ka ho sa feleng. Ha ho na lebaka la hore konofolo e bonoa e le pheko ea botsofali; Ha ho pelaelo hore konofolo e thibela lefu la pelo, e ntlafatsa phallo ea mali lithong le liseleng, e matlafatsa sesole sa 'mele le ho sireletsa 'mele linthong tse chefo. Ho phaella moo, konofolo ke pheko e babatsehang bakeng sa mafu a sa tšoaneng a nang le likokoana-hloko, libaktheria, li-fungus le likokoana-hloko.

Konofolo e na le metsoako e ikhethang e nang le sebabole, karolo ea eona e ka sehloohong e leng alliin (S-allyl-L-cysteine ​​​​sulfoxide). Alliin (e tsitsitseng) e fetoloa allicin (diallylthiosulfinate) ke enzyme alliinase ha konofolo e ncha e khangoa kapa e robeha. Allicin, ntho e sa tsitsang haholo, e ntan'o fetoloa kapele hore e be metabolites e sebetsang e fetang lekholo (thiosulfinates). Litokisetso tse ntle tsa konofolo haholo-holo li na le alliin, e fetoloang ka maleng le libakeng tse ling 'meleng hore e be metabolites e nang le phello e matla ea meriana (allicin, joalo-joalo).

Konofolo e susumetsa lintlha tse phethang karolo ea bohlokoa ho pathogenesis le tsoelo-pele ea atherosclerosis. Garlic e fokotsa maemo a kakaretso le LDL cholesterol le maemo a triglyceride, e eketsa cholesterol ea HDL e molemo, e fokotsa maemo a fibrinogen, e theola khatello ea mali ea methapo, e eketsa fibrinolysis, e thibela ho kopana ha platelet le ho fokotsa viscosity ea mali. Allicin le S-allylcysteine ​​​​li sireletsa lisele tsa endothelial le LDL cholesterol khahlano le oxidation le ho thibela atherosclerosis karolo e 'ngoe e ipapisitse le ts'ireletso ea antioxidant. Ho phaella moo, konofolo e thibela ka ho toba ts'ebetso ea atherosclerotic ka ho thibela ho ata ha lisele tse boreleli tsa mesifa ho li-plaque tsa atherosclerotic le ho bokella mafura leboteng la sekepe.

Garlic extract e theola khatello ea mali ea systemic khatellong ea mali. Hobane konofolo (in vivo) e susumetsa enzyme nitric oxide synthase ka vascular endothelium, tlhahiso ea vasodilatory nitric oxide (NO) e eketseha. Phokotso ea khatello ea mali e boetse e bakoa ke hyperpolarization ea lisele tsa mesifa tse boreleli methapong ea mali le / kapa ho thibela ho buleha ha likanale tsa calcium meleng ea mesifa. Thibelo ea angiotensin-converting enzyme (ACE), ho feto-fetoha ha prostaglandin synthesis kapa ho susumetsa ts'ebetso ea atherosclerosis le eona e ka bapala karolo.

Konofolo e nkiloeng (ho kenyeletsoa allicin, S-allylcysteine ​​​​le diallyl disulfide) e na le phello e matla ea antioxidant 'me e fana ka tšireletso khahlanong le lipid peroxidation, e thibela ho thehoa ha superoxide anion radicals le scavenges free radicals. Ho feta moo, ho noa konofolo ho lebisa keketseho ea li-enzyme tsa antioxidant catalase le glutathione peroxidase serum.
Konofolo e susumetsa mosebetsi oa macrophages, lymphocyte le lisele tse bolaeang tsa tlhaho. Ka ho thibela li-enzyme tsa lipoxygenase le cyclooxygenase, konofolo e fokotsa sebopeho se sa laoleheng sa li-eicosanoids tsa pro-inflammatory (prostaglandins, leukotrienes le thromboxanes).

Garlic e na le ts'ebetso e pharalletseng ea antimicrobial mme e sebetsa khahlano le libaktheria tsa gram-positive le gram-negative, livaerase, likokoana-hloko le litomoso le li-fungus ho kenyelletsa le Candida albicans. Ho hlahisa chefo ka likokoana-hloko tse teng ho boetse ho hanyetsanoa ke konofolo. Mabapi le matla, mg e le 'ngoe ea allicin e lekana le hoo e ka bang 15 IU ea penicillin. Garlic e boetse e sebetsa khahlanong le likokoana-hloko tsa mala. Mohlala, allicin e bolaea amoebae e bakang letšollo (Entamoeba histolytica) ka ho thibela li-cysteine ​​​​proteinase le joala dehydrogenases ho amoeba.

Allicin e kenya tšebetsong li-enzyme tsa libaktheria tsa pathogenic, livaerase le li-fungus ka ho sebetsana le sehlopha sa thiol (SH kapa sulfhydryl sehlopha) sa enzyme. Liphoofolo tse anyesang li na le liprotheine tse fokolang haholo tse nang le lihlopha tsa SH ho feta tse phelang tse tlase. Ka hona, 'meleng oa motho, glutathione e sireletsa lihlopha tsa thiol khahlanong le tšenyo. Ka lehlohonolo, likokoana-hloko tse nang le kutloelo-bohloko ho konofolo ha li khone ho hlahisa ho hanyetsa konofolo ka lebaka la ts'ebetso e tebileng ea konofolo.
Liphuputso tsa in vitro le in vivo li bontšitse hore konofolo e matlafatsa sesole sa 'mele, karolo e 'ngoe ka lebaka la phello ea garlic antioxidant. Allicin le metabolite tse ngata tse kenyelletsang diallyl sulfide (DAS), diallyl disulfide (DADS) le gamma-glutamyl-methylselenocysteine ​​​​(GGMSC) li ikarabella bakeng sa sena.

Di- le trisulfides le allyl mercaptan tse tsoang konofolo le tsona li chelate litšepe tse boima tse kang mercury, cadmium le lead. Ha e le hantle, likarolo tse ka har'a konofolo li etsa hore ho be le li-enzyme tsa karolo ea II ea ho tlosa chefo sebeteng le lithong tse ling, tse ntlafatsang ho senyeha le ho ntša chefo le ho sireletsa 'mele khahlanong le metabolites e sebetsang haholo ho tloha ho detoxification ea mohato oa pele. Konofolo e sireletsa sebete khahlanong le lintho tse chefo tse kang aflatoxin, benzopyrene le acetaminophen. Phello ea konofolo e fokotsehile haholo ha konofolo e ncha e futhumetse.

Ho tloha meriana ea setso hoa tsebahala hore konofolo e tšehetsa tšilo ea lijo, e loantša dysbiosis le ho khothalletsa takatso ea lijo.

Garlic e ka fokotsa maemo a tsoekere ea mali. Bonyane ke seo lipatlisiso tsa liphoofolo li se bontšang. Lithuto tsa batho ha li hlake hakaalo. Konofolo e ka ntlafatsa tlhahiso ea insulin le ho etsa hore insulin e sebetse butle.

Contraindications

E-ba hlokolosi ha u sebelisa motsoako oa allium sativum pele le hang ka mor'a ho buuoa le ha u sebelisa meriana ea anticoagulant (e kang warfarin, indomethacin le aspirin), kaha konofolo e liehisa ho phalla ha mali. Allium sativum extract e hanyetsanoa tabeng ea hypersensitivity ho konofolo le tšebeliso ea li-protease inhibitors khahlanong le kokoana-hloko ea HIV. Konofolo e ka fokotsa haholo boemo ba mali ba li-protease inhibitors.

Litla-morao

Ka linako tse ling tšebeliso ea li-extracts tsa Allium sativum (haholo-holo ka tekanyo e phahameng) e lebisa ho ho nyekeloa ke pelo, ho tsekela, ho tletleba ka mpeng kapa ho teneha ha lera la mucous ka har'a pampitšana ea gastrointestinal. Ho fokotsa lethal dose hangata ho rarolla litletlebo tse joalo. Ha e le hantle, ho ka khoneha, empa ke ntho e sa tloaelehang haholo. Konofolo e halikiloeng ha e na litla-morao tse fokolang.

Litšebelisano

E-ba hlokolosi ha u sebelisa litlhare tse theolang tsoekere ea mali (li-sulfonylureas), hobane ha li kopane le konofolo, boemo ba tsoekere ea mali bo ka theoha haholo. Konofolo e nkiloeng e ka boela ea matlafatsa phello ea li-statins (litlhare tse theolang k'holeseterole) le ACE inhibitors (meriana e khahlanong le khatello e phahameng ea mali). Tšebeliso ea litekanyetso tse phahameng tsa Allium sativum extract ha e khothalletsoe ka mabaka a tšireletso ha u sebelisa meriana e boletsoeng ka holimo. Qetellong, hoa tsebahala hore Allium sativum extract e ka ba le phello ea lithibela-mafu.

Mohloli: Motheo oa Naura